the role of t-l ymphocyte subpopulation in renal allograft rejection
Authors
abstract
twenty-two recipients of hla-nonidentical living related and nonrelated renal allografts were studied for alterations in the relative percentage of okt4-positive peripheral blood t-cells after transplantation. characteristic shifts in the ratio of t-helper to t -suppressor/cytotoxic cells (th/ts-c), but not absolute cell numbers, were demonstrated to correspond with the status of the allograft. our results are indicative of a correlation between rejection episodes and the increase in okt4:0kt8 ratios, that were characterized by a significant rise in the percentage of okt4-positive cells (p=0.001), and a decrease in the percentage of okt8-positive cells (p=0.001).
similar resources
THE ROLE OF T-L YMPHOCYTE SUBPOPULATION IN RENAL ALLOGRAFT REJECTION
Twenty-two recipients of HLA-nonidentical living related and nonrelated renal allografts were studied for alterations in the relative percentage of OKT4-positive peripheral blood T-cells after transplantation. Characteristic shifts in the ratio of T-helper to T -suppressor/cytotoxic cells (TH/TS-C), but not absolute cell numbers, were demonstrated to correspond with the status of the allog...
full textThe role of cytotoxic T lymphocytes in corneal allograft rejection.
PURPOSE Immunologic rejection constitutes a major barrier to the success of allogeneic corneal transplants, but the specific mediators and mechanisms of graft rejection are poorly understood. Several studies have implicated cytotoxic T-lymphocyte (CTL) responses, typically associated with CD8(+) T cells, in promoting corneal graft rejection. This study sought to test the hypothesis that CTLs ar...
full textthe analysis of the role of the speech acts theory in translating and dubbing hollywood films
از محوری ترین اثراتی که یک فیلم سینمایی ایجاد می کند دیالوگ هایی است که هنرپیش گان فیلم میگویند. به زعم یک فیلم ساز, یک شیوه متأثر نمودن مخاطب از اثر منظوره نیروی گفتارهای گوینده, مثل نیروی عاطفی, ترس آور, غم انگیز, هیجان انگیز و غیره, است. این مطالعه به بررسی این مسأله مبادرت کرده است که آیا نیروی فراگفتاری هنرپیش گان به مثابه ی اعمال گفتاری در پنج فیلم هالیوودی در نسخه های دوبله شده باز تولید...
15 صفحه اولThe role of CD8+ T cells during allograft rejection.
Organ transplantation can be considered as replacement therapy for patients with end-stage organ failure. The percent of one-year allograft survival has increased due, among other factors, to a better understanding of the rejection process and new immunosuppressive drugs. Immunosuppressive therapy used in transplantation prevents activation and proliferation of alloreactive T lymphocytes, altho...
full textMechanisms of Renal Allograft Rejection
Rejection is the major cause of graft failure, and if the injury to the tubules and glomeruli is severe, the kidney may not recover. It is therefore important to diagnose acute rejection as soon as possible to institute prompt antirejection therapy. Generally, the success with which rejection can be reversed by immunosuppressive agents determines the chance of long-term success of the transplan...
full textRole of Memory T Cells in Allograft Rejection and Tolerance
Memory T cells are characterized by their low activation threshold, robust effector functions, and resistance to conventional immunosuppression and costimulation blockade. Unlike their naïve counterparts, memory T cells reside in and recirculate through peripheral non-lymphoid tissues. Alloreactive memory T cells are subdivided into different categories based on their origins, phenotypes, and f...
full textMy Resources
Save resource for easier access later
Journal title:
medical journal of islamic republic of iranجلد ۴، شماره ۱، صفحات ۴۷-۵۲
Hosted on Doprax cloud platform doprax.com
copyright © 2015-2023